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Is Schizophrenia genetic?

Question:
I would really appreciate some help. My husband's sister has been diagnosed with schizophrenia for 20 years, his uncle spent most of his life in an institution suffering from schizophrenia. My husband has an anti-social personality and is verbally abusive to me and I am very upset that my son (who is in his late teens) is showing severe symptoms of mental disorder. Please give me some advice as I find all this impossible to handle any more?


Answer:
I think it is generally accepted that most mental illness of this type are genetic and thus carry the very real risk of being passed onto the next and subsequent generation. For bi-polar disorder I read somewhere that the probability is something like 1 in 5. Certainly in most cases a mentally ill person will have close family members with similar illnesses. This is true in my case, where one of my sisters is currently in a psychiatric hospital (she is 21 and has been an inpatient for 11 weeks) and one of my brothers shows many of the signs of my illness, although he has never admitted to having a problem and he has not seen a doctor. I think most people agree that there is some genetic component to sz, but it is not completely genetic. Here are some statistics on the probability of a child eventually contracting sz based on some relative who has the disease: Parent: 4.4% Childen of two sz parents: 37% Uncles & aunts: 2% Siblings: 8% Statistics like these are not necessarily highly reliable. Keep in mind that the incidence with no family history of sz is still 1% or 1.5%. In the case of identical twins (who are genetically identical), if one twin contracts sz, the odds are about 40% or 50% that the other will too. This means, of course, that there is SOMETHING ELSE that accounts for the other 50%. Everyone agrees, but no one has proven what that is. There was a genetics guru who posted a couple times here a few months ago who argued that sz was the result of some infection, & these genetic results were the result of an inherited susceptability to this infection. He said that polio, which has been proven to be caused by infection, has similar inheritance statistics. You might find that NAMI offers some support to you. NAMI is a volunteer organization of mainly relatives of people with serious mental disorders. They have local chapters in most places. www.nami.org. SZ is seen in many of my relatives, some mild and others severe, my dad being like a child all of his life and manic as well as my mother, but many behavior patterns were learned rather than inherited, since things changed a great deal after spending a few years in the military where the whole way of life changed and disipline being what was most needful to learn which was never taught in childhood or practiced, things going downhill again after military service when I again chose a bad way to go in not being responsible for my actions and wreckless which only led to the psycho ward and I did that to myself which would not have happened if I had retained the same level of dicipline in my life and thinking, can not blame the parents of grandparents for that. I have an older brother (have to be careful here) who is a scientist at Lawrance Livermore, I am the Neandrathal of the family while he came out almost opposite and more balanced between the ears, he was tame and I was wild, thinking that the company we kept had a lot to do with that, thinking I am the only one of the old wild bunch that did not end up in prison while the people my brother grew up with are all professional people, attorneys, shrinks, doctors and successful business people as well as my brothers wife who is the VP of Mills College for women. Moral values play a big part in the choices we make in life, but all we have now is now and where we go from here. My daughter chose to stick it out in a disfunctional family of her own but sure need people who choose not to be losers and support each other, people who endure the toughest of things and win, going one day at a time, too late to regret what we were or things we wish we had done to avoid being where we are, need the heart of a warrior who is balance with the kind of love that endures hard times and why people need people who have these qualities. There is a genetic component to schizophrenia but it is less than that for affective disorders like bipolar. Where did you find this info? It seems to me important, and I'd be grateful for a lead on sources. Go look in WWW.SCHIZOPHRENIA.COM There is a lot of good information there, including the answer to your question, and links to other sites. Your husband's anti-social personality and violent temper may be a subclinical form of mental illness (that is, not severe enough to warrant a diagnostic label) due largely to some form of chemical imbalance in the brain. Sometimes, no amount of counselling or advice can change them because of the underlying chemical imbalance (the exact nature of which we don't know). Discuss his condition with a psychiatrist. Sometimes a small dose of medication (such as risperidone 0.5mg or olanzepine 2.5mg) can do much to alleviate the suffering of people like your husband. Once his temper is under control, there will be peace in the household and your son's condition may improve at the same time. A vicious cycle is converted into a virtuous cycle.



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